Clinical and genetic aspect of resistant depression in adolescents

The work considers and distinguishes the psychopathological symptom complexes of depression in adolescents that are resistant to therapy: anxious, obsessive, behavioral. level spontaneous induced mutagenesis blood lymphocytes with was determined vitro, which twice chromosomal aberrations after introducing a mutagen into culture mixture, indicates pronounced individual group hidden instability patients depression. constants lack effectiveness therapeutic intervention were (infantilism, personal anxiety, cogni- tive component depression, noncompliance, addictions, comorbidity anorexia nervosa, suicidal behavior, recurrent insufficient titration antidepressant medication, unpleasant side effects antidepressants).